The extracranial terminal branches of the external carotid artery were suspected to be the reason of pain in the aura [ 11 , 12 ]. Comparing inflammatory substances in one of our studies [ 35 ] plasma C Reactive Protein, ICAM-1, ADMA, sPLA2 concentrations and HOMA-IR were found to be significantly higher in morbidly obese patients than in controls, suggesting that; obesity, glucose disruptions, and insulin resistance appear to be associated with endothelial dysfunction as well as low-grade inflammation caused by the release of pro-inflammatory cytokines by macrophages.
In their study, migraine prevalence was increased with total body obesity, independently of abdominal obesity, in adult men and women who are less than 55 years of age. On the other hand, multiple recent studies with a focus on surgical weight loss in obese migraineurs have suggested that weight loss may be beneficial for improving headache pain and frequency. The system contains orexigenic and anorexigenic neuropeptides that are the main regulators of energy expenditure and appetite.
Their findings showed significant postoperative reductions in headache severity as well as a reduction in the percentage of participants with a moderate-to-severe disability. Fat intake is also found be associated with CGRP secretion.
Elevated serum leptin is found to be associated with an increase in the anorexigenic pro-opiomelanocortin expression and a decrease in orexigenic NPY and AgRP [ 64 - 66 ]. In another population-based study, they found that BMI group was not associated with the prevalence of migraine but the frequency of headache attacks, as headache days per month was higher in obese and the morbidly obese group.